SEPT12–NDC1 Complexes Are Required for Mammalian Spermiogenesis
نویسندگان
چکیده
منابع مشابه
SEPT12–NDC1 Complexes Are Required for Mammalian Spermiogenesis
Male factor infertility accounts for approximately 50 percent of infertile couples. The male factor-related causes of intracytoplasmic sperm injection failure include the absence of sperm, immotile sperm, immature sperm, abnormally structured sperm, and sperm with nuclear damage. Our knockout and knock-in mice models demonstrated that SEPTIN12 (SEPT12) is vital for the formation of sperm morpho...
متن کاملUbiquitin-Ligase Complexes Are Required for Jasmonate Response in Arabidopsis
a Institute of Biotechnology Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China b Institute of Molecular Agrobiology, 1 Research Link, National University of Singapore, 117604, Republic of Singapore c Institut de Biologie Moléculaire des Plantes du Centre National de la Recherche Scientifique, 12 Rue du Général Zimmer, 67084 Strasbourg Cédex, France d Plant Biotechnology ...
متن کاملSix5 is required for spermatogenic cell survival and spermiogenesis.
Myotonic dystrophy 1 (DM1) is a multi-system disorder characterized by endocrine defects that include testicular and tubular atrophy, oligospermia, Leydig cell hyperproliferation and increased follicle stimulating hormone (FSH) levels. DM1 results from a CTG expansion that causes transcriptional silencing of the flanking SIX5 allele. Loss of Six5 results in male sterility and a progressive decr...
متن کاملIQ Motif-Containing G (Iqcg) Is Required for Mouse Spermiogenesis
Spermiogenesis in mammals is the process by which the newly formed products of meiosis, haploid spermatids, undergo a dramatic morphological transformation from round cells into flagellated spermatozoa. The underlying genetic control of spermiogenesis is complicated and not well-characterized. We have used forward genetic screens in mice to illuminate the mechanisms of spermatozoon development....
متن کاملCHD5 is required for spermiogenesis and chromatin condensation
Haploid spermatids undergo extensive cellular, molecular and morphological changes to form spermatozoa during spermiogenesis. Abnormalities in these steps can lead to serious male fertility problems, from oligospermia to complete azoospermia. CHD5 is a chromatin-remodeling nuclear protein expressed almost exclusively in the brain and testis. Male Chd5 knockout (KO) mice have deregulated spermat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2016
ISSN: 1422-0067
DOI: 10.3390/ijms17111911